反应详情

To a solution of p-nitrobenzyl α-[4-cyclopropylmethoxycarbonylthio-3-phenoxyacetamido-2-oxoazetidin-1-yl]-α-(1-methanesulfonyloxyethylidene)acetate (1.12 g) in benzene (11 ml) is added morpholine (0.26 ml) under ice cooling, and the mixture is kept at 10° C overnight. The reaction mixture is washed with water, dried, and evaporated under reduced pressure. Purification of the obtained residue (1 g) by chromatograaphy over silica gel (10 g) using a mixture of benzene and ethyl acetate (1:2) gives p-nitrobenzyl α-[4-cyclopropylmethoxycarbonylthio-3-phenoxyacetamido-2-oxoazetidin-1-yl]-α-(1-morpholinoethylidene)acetate (602 mg). Foam. IR: νmaxCHCl3 3430, 1774, 1694br, 1604, 1105, cm-1. NMR: δCDCl3 0.22m5H, 2.27+2.24s3H, 3.43m4H, 3.77m4H, 4.02d(6.4Hz)2H, 4.57s2H, 5.05-5.27m3H, 5.89d(5.4Hz)1H, 4.12-7.65m7H, 8.23d(8.4Hz)2H.

1. washThe reaction mixture is washed with water
2. customdried
3. customevaporated under reduced pressure
4. customPurification of the obtained residue (1 g) by chromatograaphy over silica gel (10 g)
5. additiona mixture of benzene and ethyl acetate (1:2)