Ethanol → HCID 12822167, compound

HRID 1679264Notes

Reaction equation

HRID 1679264 reaction equation
[F:1][C:2]1[CH:31]=[CH:30][C:5]([O:6][CH2:7][CH:8]([O:26]C(=O)C)[CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([N:16]3[C:20]4[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=4[NH:18][C:17]3=[O:25])[CH2:12][CH2:11]2)=[CH:4][CH:3]=1.[OH-].[K+].C(O)C>O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][CH:8]([OH:26])[CH2:9][N:10]2[CH2:11][CH2:12][CH:13]([N:16]3[C:20]4[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=4[NH:18][C:17]3=[O:25])[CH2:14][CH2:15]2)=[CH:30][CH:31]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 12822177HCID 12822177, compound

Product 1

HCID 12822167HCID 12822167, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A mixture of 2.2 g of 1-{1-[3-(p-fluorophenoxy)-2-acetyloxypropyl]-4-piperidyl}-2-oxobenzimidazoline, 1.1 g of potassium hydroxide, 5 ml of water and 20 ml of ethanol is stirred at room temperature for one hour. The reaction mixture is poured into 200 ml of water. After cooling, the precipitate formed is collected by filtration and dried to give 1-{1-[3-(p-fluorophenoxy)-2-hydroxypropyl]-4-piperidyl}-2-oxobenzimidazoline, m.p. 175° - 176° C. Recrystallization from benzene gives white crystals, m.p. 177° - 178° C.

Workup

  1. temperatureAfter cooling
  2. customthe precipitate formed
  3. filtrationis collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-a93169438dcc48fbba616cf7cfe7a623
Source dataset
uspto-grants-1978_03
Patent number
US04080328

Reaction notes

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