Hydrochloric Acid → HCID 20362322, compound

Participants

Reaction Steps

To a mixture of 0.2 g of sodium borohydride in 10 ml of ethanol is added dropwise a solution of 2 g of 1-phenyl-8-[3-(p-fluorophenoxy)-2-oxopropyl]-4-oxo-1,3,8-triazaspiro[4,5]decane in 20 ml of ethanol. The mixture is stirred at room temperature for five hours. The resulting mixture is decomposed with 2N hydrochloric acid, diluted with water, made alkaline with sodium hydroxide and diluted again with water. After cooling, the precipitate is collected by filtration and dried to give 1-phenyl-8-[3-(p-fluorophenoxy)-2-hydroxypropyl]-4-oxo-1,3,8-triazaspiro[4,5]decane, m.p. 152° - 154° C. Recrystallization from iso-propanol gives pale yellow crystals, m.p. 164° - 166° C.

Provenance & Evidence