HCID 178463631, compound → HCID 178463413, compound

HRID 1679268Notes

Reaction equation

HRID 1679268 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([CH2:8]C(O)=O)[N:5]=[C:4]([NH:12][CH2:13][CH3:14])[N:3]=1>C(O)C>[OH:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([NH:12][CH2:13][CH3:14])[N:3]=1

Participants

3

Reactant 1

HCID 178463631HCID 178463631, compound

Product 1

HCID 178463413HCID 178463413, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-Hydroxy-2-ethylaminopyrimidin-6-yl acetic acid was suspended in ethanol (50 ml) and the mixture refluxed for 16 hours. Evaporation of the ethanol under reduced pressure yielded chromatographically pure 4-hydroxy-2-ethylamino-6-methylpyrimidine, melting at 176° C.

Workup

  1. temperaturethe mixture refluxed for 16 hours
  2. customEvaporation of the ethanol under reduced pressure

Sources & evidence

ORD record
ord-a60a2ddebe1d41f089b3e4e9a5e9625a
Source dataset
uspto-grants-1978_03
Patent number
US04080326

Reaction notes

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