HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Azide → 2-Azido-1-(3-phenyl-2,3-dihydro-1H-indol-1-yl)ethan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 2-Chloro-1-(3-phenyl-2,3-dihydro-1H-indol-1-yl)ethan-1-one | HCID 21320458 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Azido-1-(3-phenyl-2,3-dihydro-1H-indol-1-yl)ethan-1-one | HCID 21320467 | 68.3% |
Reaction Steps
A solution of 4.0 g of N-chloracetyl-3-phenylindoline and 1.1 g of sodium azide in 70 ml of 80% aqueous ethanol was refluxed for one hour. After cooling, the solution was diluted with 100 ml of water and extracted with methylene chloride. Evaporation of the solvent gave 2.8 g of the desired N-azidoacetyl-3-phenylindoline having a melting point of 72°-3° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04080330 |
| Source dataset | uspto-grants-1978_03 |
| ORD ID | ord-68cbe847d7834afea8a0538a5d9037cf |
| Source note | uspto-grants-1978_03 |