Benzaldehyde → HCID 20362659, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 73 g. of phosphorus pentoxide and 43.5 ml. of 85% phosphoric acid, rendered homogeneous by heating at 170° C., is added at room temperature a solution of 9.0 g. (0.05 moles) of 3-(3-methoxyphenyl)-propionamide and 5.9 g. (0.055 moles) of benzaldehyde in 104 ml. of glacial acetic acid. Stirring under an atmosphere of nitrogen is maintained for 3 days and then the reaction mixture is poured into 1 liter water; a precipitate appears, which is filtered off, washed neutral with water and dried. After separation by chromatography and recrystallization from ethanol, 1.5 g. (11% of theory) of pure 7-methoxy-1-phenyl-1,2,4,5-tetrahydro-3H-2-benzazepin-3-one is obtained. M.P. 185-186° C.

Provenance & Evidence