1,1-Bis(methylthio)-2-nitroethylene → 1-Nitro-2-methylthio-2-[2-(2-pyridylmethylthio)ethylamino]ethylene

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Reaction Steps

A solution of 2-[(2-aminoethyl)thiomethyl]pyridine (5.0 g) and 1-nitro-2,2-bis-methylthioethylene (5.28 g) in ethanol was heated under reflux for 3 hours. Concentration and chromatographic purification of the product on a column of silica gel with elution by iso-propyl alcohol-ethylacetate (1:5) gave 1-nitro-2-methylthio-2-[2-(2-pyridylmethylthio)ethylamino]ethylene (2.49 g), m.p. 95.5°-96.5°.

Provenance & Evidence