1,1-Bis(methylthio)-2-nitroethylene → 1-Nitro-2-methylthio-2-[4-(4-imidazolyl)butylamino]ethylene

Participants

Reaction Steps

A solution of 4-(4-aminobutyl)imidazole (from the dihydrobromide (3.6 g) and 1-nitro-2,2-bis-methylthio-ethylene (2.0 g)) in acetonitrile (50 ml) was set aside at room temperature for 3 days. The product was chromatographed on a column of silica gel with clution by ethyl acetate, to give 1-nitro-2-methylthio-2-[4-(4-imidazolyl)butylamino]ethylene.

Provenance & Evidence