Ethanol → l-1-Cyclohexyl-4-[1-phenyl-2-(3-tolyl)ethyl]piperazine dibenzoyl-d-tartarate sesquihydrate

Participants

Reaction Steps

A warmed mixture of dl-1-cyclohexyl-4-[1-phenyl-2-(3-tolyl)ethyl]piperazine (3.0 g), dibenzoyl-d-tartaric acid monohydrate (3.2 g) and ethanol (100 ml) is allowed to cool. The precipitated crystals are separated by filtration and fractionally recrystallized from 95 % ethanol to give l-1-cyclohexyl-4-[1-phenyl-2-(3-tolyl)ethyl]piperazine dibenzoyl-d-tartarate sesquihydrate (1.2 g), melting point: 150°-151° C (decomp.), [α]D/28 = -83.0° (c=1.0, methanol).

Provenance & Evidence