Sodium Hydroxide → 4-[(Methoxymethyl)sulfanyl]-2-nitroaniline

HRID 1679456Notes

Reaction equation

HRID 1679456 reaction equation
C([NH:4][C:5]1[CH:10]=[CH:9][C:8]([S:11][CH2:12][O:13][CH3:14])=[CH:7][C:6]=1[N+:15]([O-:17])=[O:16])(=O)C.[OH-].[Na+]>CO>[NH2:4][C:5]1[CH:10]=[CH:9][C:8]([S:11][CH2:12][O:13][CH3:14])=[CH:7][C:6]=1[N+:15]([O-:17])=[O:16]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 20362834N-{4-[(Methoxymethyl)sulfanyl]-2-nitrophenyl}acetamide

Product 1

HCID 203628174-[(Methoxymethyl)sulfanyl]-2-nitroaniline

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.4 G. of 1-acetamido-2-nitro-4-methoxymethylthiobenzene is treated with 3 ml. 5N sodium hydroxide and 6 ml. methanol in the steam bath for about 15 minutes. The mixture is stripped under vacuum and the residue extracted with chloroform. The dried extracts are evaporated giving 1-amino-2-nitro-4-methoxymethylthiobenzene as a red crystalline solid.

Workup

  1. extractionthe residue extracted with chloroform
  2. customThe dried extracts are evaporated

Sources & evidence

ORD record
ord-d9659431342b467bb5aa40379a4b35e9
Source dataset
uspto-grants-1978_03
Patent number
US04080461

Reaction notes

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