Acetic Anhydride → HCID 20363160, compound

Participants

Reaction Steps

In 3 ml of toluene is dissolved 2.8 g of 2-chloro-3-[4-(2,2-dimethyl-2-phenylethyloxy)phenyl]propionamide, and to the solution are added 1.0 g of acetic anhydride and one drop of concentrated sulfuric acid. The mixed solution is stirred under heating at 100° to 110° C for 1.5 hour. After cooling, the solvent is distilled off and water is added to the residue. The resulting crystals are recrystallized from ethanol to give 2.8 g of N-acetyl-2-chloro-3-[4-(2,2-dimethyl-2-phenylethyloxy)phenyl]propionamide.

Provenance & Evidence