HCID 70573350, compound → HCID 70571741, compound

HRID 1679517Notes

Reaction equation

HRID 1679517 reaction equation
[ClH:1].CC1(C)CC(C2C=CC=C([C:19]([F:22])([F:21])[F:20])C=2)C2C(=CC(OCCNC)=CC=2)O1.Cl.[CH3:30][C:31]1([CH3:53])[CH2:40][CH:39]([C:41]2[CH:46]=[CH:45][C:44](F)=[CH:43][CH:42]=2)[C:38]2[C:33](=[CH:34][C:35]([O:48][CH2:49][CH2:50][NH:51][CH3:52])=[CH:36][CH:37]=2)[O:32]1.Cl.CC1(C)CC(C2C=CC=CC=2)C2C(=CC(OCCNC)=CC=2)O1.Cl.CC1(C)CC(C2C=CC=C(F)C=2)C2C(=CC(OCCN(C)C)=CC=2)O1>>[ClH:1].[CH3:30][C:31]1([CH3:53])[CH2:40][CH:39]([C:41]2[CH:46]=[CH:45][C:44]([C:19]([F:22])([F:21])[F:20])=[CH:43][CH:42]=2)[C:38]2[C:33](=[CH:34][C:35]([O:48][CH2:49][CH2:50][NH:51][CH3:52])=[CH:36][CH:37]=2)[O:32]1

Participants

5

Reactant 4

HCID 70573350HCID 70573350, compoundHCID 70573610HCID 70573610, compoundHCID 70574262HCID 70574262, compoundHCID 70575094HCID 70575094, compound

Product 1

HCID 70571741HCID 70571741, compound

Procedure

A strictly analogous procedure led to the production of 2,2-dimethyl-7-methylaminoethyloxy-4-(3-trifluoromethylphenyl)chroman hydrochloride, m.p. 182°-184° C, to 2,2-dimethyl-7-methylaminoethyloxy-4-(4-fluorophenyl)chroman hydrochloride, m.p. 222°-224° C, to 2,2-dimethyl-7-methylaminoethyloxy-4-phenylchroman hydrochloride, m.p. 191°-193° C, and to 2,2-dimethyl-7-dimethylaminoethoxy-4-(3-fluorophenyl)chroman hydrochloride, m.p. 168°-171.5° C.

Sources & evidence

ORD record
ord-ca2580d8c2e241159620eced3da5a851
Source dataset
uspto-grants-1978_03
Patent number
US04080335

Reaction notes

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