2-((3,4-Dihydro-2,2-dimethyl-4-(4-(trifluoromethyl)phenyl)-2H-1-benzopyran-7-yl)oxy)-N,N-dimethylethanamine → 7-[2-(N-benzyl-N-methylamino)ethoxy]-2,2-dimethyl-4-(2-naphthyl)-2H-chromene

Participants

Role	Name	HCID	Charge
Reactant	2-((3,4-Dihydro-2,2-dimethyl-4-(4-(trifluoromethyl)phenyl)-2H-1-benzopyran-7-yl)oxy)-N,N-dimethylethanamine	HCID 42990	—
Reactant	N-(2-Chloroethyl)-N-methylbenzylamine hydrochloride	HCID 12822620	—
Reactant	2,2-Dimethyl-4-(naphthalen-2-yl)-2H-1-benzopyran-7-ol	HCID 20570540	—
Product	7-[2-(N-benzyl-N-methylamino)ethoxy]-2,2-dimethyl-4-(2-naphthyl)-2H-chromene	HCID 20570503	49%

Reaction Steps

Reaction of N-benzyl-N-(2-chloroethyl)methylamine hydrochloride with 2,2-dimethyl-4-(2-naphthyl)-2H-chromen-7-ol by an analogous method to that described in Preparation 18 (c) gave the title compound (49%) as a colourless oil, The hydrochloride salt had m.p. 112°-115° C decomposed.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04080335
Source dataset	uspto-grants-1978_03
ORD ID	ord-f7c9a5dab54c490aa3e71629fe9d9892
Source note	uspto-grants-1978_03