1,1,2-Trichloroethane → p-Nitrobenzyl 3-Methyl-2-(2-chlorosulfinyl-4-oxo-3-formamido-1-azetidinyl)-3-butenoate

HRID 1679566노트

반응식

HRID 1679566 반응식
[CH:1]([NH:3][C@@H:4]1[C:26](=[O:27])[N:6]2[CH:7]([C:13]([O:15][CH2:16][C:17]3[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][CH:18]=3)=[O:14])[C:8]([CH3:12])([CH3:11])[S:9](=[O:10])[C@H:5]12)=[O:2].[Cl:28]N1C(=O)CCC1=O.ClC(Cl)CCl>>[CH3:11][C:8](=[CH2:12])[CH:7]([N:6]1[C:26](=[O:27])[CH:4]([NH:3][CH:1]=[O:2])[CH:5]1[S:9]([Cl:28])=[O:10])[C:13]([O:15][CH2:16][C:17]1[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][CH:18]=1)=[O:14]

참가 물질

4

반응물 3

HCID 65741,1,2-TrichloroethaneHCID 31398ChlorosuccinimideHCID 86735569p-Nitrobenzyl 6beta-formamido-2,2-dimethylpenam-3-carboxylate-1-oxide

생성물 1

HCID 20349500p-Nitrobenzyl 3-Methyl-2-(2-chlorosulfinyl-4-oxo-3-formamido-1-azetidinyl)-3-butenoate

실험 절차

A solution of 1.43 g. of p-nitrobenzyl 6β-formamido-2,2-dimethylpenam-3-carboxylate-1-oxide and 500 mg. of N-chlorosuccinimide in 40 ml. of dry 1,1,2-trichloroethane was refluxed for 90 minutes. The mixture was cooled, washed with water and brine, dried over MgSO4, and the solvent was evaporated. The nmr spectrum indicates conversion to the title compound.

후처리

  1. temperatureThe mixture was cooled
  2. washwashed with water and brine
  3. dry with materialdried over MgSO4
  4. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-bdb2d98fe60145a39a49d8b8a31dcef7
출처 데이터셋
uspto-grants-1978_03
특허 번호
US04081440

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