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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1679586Generated: October 30, 2026

Triethylamine → 1H-1,4-Benzodiazepine

https://huagongshe.com/reaction/1679586

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTriethylamineHCID 8471—
ReactantN-HydroxyphthalimideHCID 10665—
Reactant8-nitro-1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepineHCID 23337467—
SolventDimethylacetamideHCID 31374—
Product1H-1,4-BenzodiazepineHCID 148431—

Reaction Steps

In the manner given in Example 1, N-hydroxyphthalimide and triethylamine in dimethylacetamide is treated with 8-nitro-6-(o-chlorophenyl)-1-(chloromethyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine to give 8-nitro-6-(o-chlorophenyl)-1-[(phthalimidooxy)methyl]-4H-s-triazolo][4,3-a][1,4]benzodiazepine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04081452
Source datasetuspto-grants-1978_03
ORD IDord-8dbd8e62f124414595833ef57f916b28
Source noteuspto-grants-1978_03