HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 8-bromo-1-[(phthalimidooxy)methyl]-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | N-Hydroxyphthalimide | HCID 10665 | — |
| Reactant | 8-bromo-1-(chloromethyl)-6-(2-pyridyl)-4H-s triazolo[4,3-a][1,4]benzodiazepine | HCID 20361200 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 8-bromo-1-[(phthalimidooxy)methyl]-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine | HCID 20361184 | — |
Reaction Steps
In the manner given in Example 1, N-hydroxyphthalimide and triethylamine in dimethylacetamide is treated with 8-bromo-6-(2-pyridyl)-1-(chloromethyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine to give 8-bromo-6-(2-pyridyl)-1-[(phthalimidooxy)methyl]-4H-s-triazolo[4,3-a][1,4]benzodiazepine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04081452 |
| Source dataset | uspto-grants-1978_03 |
| ORD ID | ord-677d4329ac0d49edbd9acf7bcbb8a998 |
| Source note | uspto-grants-1978_03 |