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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1679601Generated: October 30, 2026

Methylhydroxylamine → HCID 20361183, compound

https://huagongshe.com/reaction/1679601

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethylhydroxylamineHCID 11647—
ReactantSodium hydrideHCID 24758—
Reactant8-bromo-1-(chloromethyl)-6-(2-pyridyl)-4H-s triazolo[4,3-a][1,4]benzodiazepineHCID 20361200—
SolventDimethylformamideHCID 6228—
ProductHCID 20361183HCID 20361183—

Reaction Steps

In the manner given in Example 16, a solution of N-methylhydroxylamine in dimethylformamide is treated with sodium hydride suspended in mineral oil, and the mixture is treated with 8-bromo-1-(chloromethyl)-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine to give 8-bromo-1-[(methylhydroxyamino)methyl]-6-(2-pyridyl)4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04081452
Source datasetuspto-grants-1978_03
ORD IDord-1c430b38cb634f44b29a9a38da155c32
Source noteuspto-grants-1978_03