Pyridine → tetrahydro-1-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)-3-methyl-6-(4-cyanophenoxycarbonyloxy)-2(1H)-pyrimidinone

HRID 167961Notes

Reaction equation

HRID 167961 reaction equation
[Cl:19][C:20](=[O:21])[O:22][c:23]1[cH:24][cH:25][c:26]([C:29]#[N:30])[cH:27][cH:28]1.[F:1][C:2]([c:3]1[n:4][n:5][c:6]([N:8]2[C:9](=[O:16])[N:10]([CH3:15])[CH2:11][CH2:12][CH:13]2[OH:14])[s:7]1)([F:17])[F:18].[cH:31]1[cH:32][cH:33][n:34][cH:35][cH:36]1>>[F:1][C:2]([c:3]1[n:4][n:5][c:6]([N:8]2[C:9](=[O:16])[N:10]([CH3:15])[CH2:11][CH2:12][CH:13]2[O:14][C:20](=[O:21])[O:22][c:23]2[cH:24][cH:25][c:26]([C:29]#[N:30])[cH:27][cH:28]2)[s:7]1)([F:17])[F:18]

Participants

4

Reactant 3

HCID 1049PyridineHCID 159176024-Cyanophenyl chloroformateHCID 21400101tetrahydro-1-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)-3-methyl-6-hydroxy-2(1H)-pyrimidinone

Product 1

HCID 21418659tetrahydro-1-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)-3-methyl-6-(4-cyanophenoxycarbonyloxy)-2(1H)-pyrimidinone

Sources & evidence

ORD record
ord-a9edbe6ae188497881c2d720b1a0d46f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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