反应详情

A mixture of equimolar quantities of 5,5-dimethyl-10-hydroxy-8-(4-fluorophenyl-1-methylbutyl)-2-(2-propynyl)-1,2,3,4-tetrahydro-5H[1]benzopyrano[3,4-d]pyridine, γ-(2-methylpiperidino)butyric acid hydrochloride and dicyclohexylcarbodiimide in methylene chloride are stirred at room temperature for 16 hours. The reaction mixture is cooled and the solid removed by suction filtration. The methylene chloride is evaporated to give a residue which is dissolved in methylene chloride and diethyl ether. After removing the resulting crude product, the solvents are evaporated and the gummy resin is dried, triturated with diethyl ether, and dried to yield the desired product.

1. temperatureThe reaction mixture is cooled
2. customthe solid removed by suction filtration
3. customThe methylene chloride is evaporated
4. customto give a residue which
5. customAfter removing the resulting crude product
6. customthe solvents are evaporated
7. customthe gummy resin is dried
8. customtriturated with diethyl ether
9. customdried