Sodium Hydroxide → HCID 178524730, compound

HRID 1679679Notes

Reaction equation

HRID 1679679 reaction equation
[OH:1][C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[CH:4][C:3]=1[C:11]([O:13]CC)=[O:12].[OH-].[Na+]>C(O)(=O)C>[OH:1][C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[CH:4][C:3]=1[C:11]([OH:13])=[O:12]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178469627HCID 178469627, compound

Product 1

HCID 178524730HCID 178524730, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of ethyl 7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylate (0.50g., 2.4mM) and 10% sodium hydroxide solution (5ml) was heated on a steam bath for 3 hours. The reaction mixture was cooled and acidified with acetic acid to give the required product as white crystals in 76.3% weight yield (0.33%), m.p. 319°-320° C (decomposition), νmax (nujol) 1740 (acid C=O) and 1675 (lactam C=O)cm-1.

Workup

  1. temperaturewas heated on a steam bath for 3 hours
  2. temperatureThe reaction mixture was cooled

Sources & evidence

ORD record
ord-db2ffb413d8b4c27bd86f2244f8a442c
Source dataset
uspto-grants-1978_03
Patent number
US04081545

Reaction notes

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