Pyridine → HCID 86735575, compound

HRID 1679689Notes

Reaction equation

HRID 1679689 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9](=O)[CH2:10][CH2:11][CH2:12][CH2:13][C:14]#[N:15])[CH:5]=[CH:6][C:7]=1[Cl:8].Cl.Cl.[NH2:19][O:20][CH2:21][CH2:22][NH2:23].N1C=CC=CC=1>C(O)C>[ClH:1].[NH2:23][CH2:22][CH2:21][O:20][N:19]=[C:9]([C:4]1[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=1)[CH2:10][CH2:11][CH2:12][CH2:13][C:14]#[N:15]

Participants

5

Reactant 3

HCID 1049PyridineHCID 143623262-(O-aminooxy)ethylamine dihydrochlorideHCID 70626825HCID 70626825, compound

Product 1

HCID 86735575HCID 86735575, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 7.2 mmol (1.85 g) of 3', 4'-dichloro-5-cyanovalerophenone (melting point 49°-51° C), 7.2 mmol (1.08 g) of 2-aminooxyethylamine dihydrochloride, 1.0 ml of pyridine and 7 ml of absolute ethanol was refluxed for 3 hours. The reaction mixture was then further processed in a manner identical to that described in Example 1. After crystallization from an ethanol-ether mixture the above entitled compound was obtained with a melting point of 134°-135° C.

Workup

  1. temperaturewas refluxed for 3 hours
  2. customAfter crystallization from an ethanol-ether mixture the
  3. customwas obtained with a melting point of 134°-135° C.

Sources & evidence

ORD record
ord-4c290609fff2465b9090da34cee1bc36
Source dataset
uspto-grants-1978_03
Patent number
US04081552

Reaction notes

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