Hydrochloric Acid → HCID 70436618, compound

Participants

Reaction Steps

To a mixture of p-nitrobenzyl 7-(2-thienyl)acetamido-3-cephem-4-carboxylate (2.0 g), methanol (40 ml), and tetrahydrofuran (40 ml) one adds 10% hydrochloric acid (1.4 ml) and 5% palladium on carbon (1.9 g), shakes the mixture under hydrogen atmosphere (1 atm.) at room temperature for 2.5 hours, pours into water, extracts with methylene chloride, washes with water, dries, concentrates, and crystallizes from ether to give 7-(2-thienyl)acetamido-3-cephem-4-carboxylic acid (1.30 g).

Provenance & Evidence