Bromine → 2-Bromo-2-methyl-2',3'-dichloro-4'-methoxybutyrophenone

HRID 1679728Notes

Reaction equation

HRID 1679728 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([O:9][CH3:10])[CH:5]=[CH:4][C:3]=1[C:11](=[O:16])[CH:12]([CH3:15])[CH2:13][CH3:14].[Br:17]Br>C(O)(=O)C>[Br:17][C:12]([CH3:15])([CH2:13][CH3:14])[C:11]([C:3]1[CH:4]=[CH:5][C:6]([O:9][CH3:10])=[C:7]([Cl:8])[C:2]=1[Cl:1])=[O:16]

Participants

4

Reactant 2

HCID 24408BromineHCID 203584552',3'-Dichloro-4'-methoxy-2-methylbutyrophenone

Product 1

HCID 203584392-Bromo-2-methyl-2',3'-dichloro-4'-methoxybutyrophenone

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

By following the procedure described in Example 5, Step B, using as the reactants 2',3'-dichloro-4'-methoxy-2-methylbutyrophenone (26 g., 0.10 mole), acetic acid (75 ml.) and bromine (16 g., 0.10 mole), there is obtained 2-bromo-2-methyl-2',3'-dichloro-4'-methoxybutyrophenone.

Sources & evidence

ORD record
ord-b8961bb609cd48219b291a773dc5cab2
Source dataset
uspto-grants-1978_03
Patent number
US04081554

Reaction notes

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