Hydrochloric Acid → HCID 20358472, compound

Participants

Reaction Conditions

Reaction Steps

A stirred suspension of [1-oxo-2-isopropyl-2-(3-oxobutyl)-6,7-dichloro-5-indanyloxy]acetic acid (2.0 g., 0.0052 mole) in water (50 ml.) is cooled to 5° C. and treated over a 1/2 hour period with a solution of potassium borohydride (0.6 g., 0.11 mole). The reaction is stirred at 10°-15° C. for 1/2 hour then acidified with dilute aqueous hydrochloric acid affording [1-oxo-2-(3-hydroxybutyl)-2-isopropyl-6,7-dichloro-5-indanyloxy]acetic acid as a white solid which is filtered, rinsed with water and dried.

Provenance & Evidence