Nitric Acid → HCID 70627855, compound

Participants

Reaction Steps

At -20° C., 6 ml. of concentrated nitric acid is added dropwise to 8.0 g. of 15α-hydroxy-18-methyl-4-estrene-3,17-dione in 60 ml. of acetic anhydride. After 1 hour, the reaction solution is introduced into ice/water. The thus-precipitated product is vacuum-filtered, washed several times with water, taken up in methylene chloride, and dried over sodium sulfate. After chromatographing the crude product on silica gel with acetone-hexane, 6.4 g. of 18-methyl-15α-nitrooxy-4-estrene-3,17-dione is produced.

Provenance & Evidence