Sulfuric Acid → HCID 86735583, compound

Participants

Reaction Steps

Analogously to Example 13, 1.5 g. of 17β-acetoxy-17α-ethynyl-18-methyl-4,15-estradien-3-one in 40 ml. of tetrahydrofuran is reacted with 4.5 g. of lithium tri-(tert.butoxy)-aluminum hydride in 30 ml. of tetrahydrofuran. After 1 hour, the solution is introduced into ice water which contains sulfuric acid and worked up analogously to Example 13. After chromatography of the crude product on silica gel with 5-8% acetone-hexane, 530 mg. of 17β-acetoxy-17α-ethynyl-18-methyl-4,15-estradien-3β-ol is obtained.

Provenance & Evidence