Methanol → HCID 86735584, compound

Participants

Reaction Steps

As described in Example 22, 2.4 g. of 17β-acetoxy-17α-ethynyl-18-methyl-4,15-estradien-3-one in 60 ml. of methanol and 2 ml. of water is reacted with 1.0 g. of hydroxylamine hydrochloride and 1.0 g. of sodium bicarbonate. After 1.5 hours, the reaction mixture is worked up analogously to Example 22. After the crude product has been chromatographed on silica gel with acetone-hexane, 760 mg. of 17β-acetoxy-17α-ethynyl-18-methyl-4,15-estradien-3-one oxime is obtained.

Provenance & Evidence