Acetic Anhydride → HCID 131711062, compound

Participants

Reaction Steps

Under nitrogen, 250 mg. of 17β-hydroxy-18-methyl-17α-propinyl-4,15-estradien-3-one in 2.5 ml. of pyridine is agitated at room temperature for 2 hours with 1 ml. of acetic anhydride and 10 mg. of 4-(dimethylamino)-pyridine. After the reaction mixture has been worked up as described in Example 36, and after the crude product has been chromatographed on silica gel with acetone-hexane, 110 mg. of 17β-acetoxy-18-methyl-17α-propin-1-yl-4,15-estradien-3-one is obtained.

Provenance & Evidence