Toluene → HCID 20361795, compound

Participants

Reaction Conditions

Reaction Steps

At 0°-5° C add a suspension of 28.5 g. of sodamide in 300 ml. of toluene to a stirred solution containing 50 g. of p-chlorphenylacetonitrile and 40 g. of 2-chlorothiazole in 400 ml. of toluene. Maintain the temperature at 20° C for 2 hrs. and finally at 60° C for 1 hr. Consecutively add 100 ml. of water and 35 ml. of acetic acid at 0°-10° C and filter the resulting mixture. Separate the toluene layer, concentrate in vacuo and distill the residue to give α-(p-chlorphenyl)-2-thiazolylacetonitrile as a mobile yellow oil, b.p. 155°-160° C/1 mm.

Provenance & Evidence