Ethylenediamine → 2-[1-(4,5-Dihydro-1H-imidazol-2-yl)-1-phenylethyl]pyridine

Participants

Reaction Conditions

Reaction Steps

Under a nitrogen atmosphere, heat (bath at 140° C) under reflux conditions 2 g. of α-(2-pyridyl)-α-phenylthiopropionamide and 20 ml. of ethylene diamine. Evaporate off the excess diamine, dissolve the residue in benzene, filter, wash, dry and evaporate the benzene solution. Crystallize the residual pale green oil from isopropyl ether to yield 2-[α-(2-pyridyl)α-methylbenzyl]-imidazoline, m.p. 102-103° C. The maleate salt, crystallized from acetonitrile, melts at 156.5°-158° C.

Provenance & Evidence