Dimethylamine → 6-tert-Butyl-4-[(dimethylamino)methyl]-2,3-dimethylphenol

HRID 1679778Notes

Reaction equation

HRID 1679778 reaction equation
[C:1]([C:5]1[C:10]([OH:11])=[C:9]([CH3:12])[C:8]([CH3:13])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:14][NH:15][CH3:16].[CH2:17]=O>C1(C)C=CC=CC=1.CCOCC>[C:1]([C:5]1[C:10]([OH:11])=[C:9]([CH3:12])[C:8]([CH3:13])=[C:7]([CH2:14][N:15]([CH3:17])[CH3:16])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

6

Reactant 3

HCID 674DimethylamineHCID 712FormaldehydeHCID 170766Phenol, 6-(1,1-dimethylethyl)-2,3-dimethyl-

Product 1

HCID 221015906-tert-Butyl-4-[(dimethylamino)methyl]-2,3-dimethylphenol

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 3283Diethyl EtherSolvent

Procedure

To 142.4 grams of 6-tert.-butyl-2,3-dimethylphenol dissolved in 270 ml of toluene was added 144.4 grams of a 25% aqueous solution of dimethylamine at about room temperature. 65.7 Grams of 36.5% aqueous formaldehyde was then added over a 10 minute period to the reaction mixture initially at 15°, the temperature rising to 30° at the end of the addition. The reaction mixture was then warmed to 40° for 3 hours and finally heated at reflux (85°) for 2 hours. The reaction was diluted with about 1 liter of ether and the aqueous layer separated, the upper ether layer being washed three times with water. After drying over sodium sulfate, the organic phase was stripeed to dryness at reduced pressures yielding 176.3 grams of crude product. The crude product was crystallized form heptane, yielding white crystals melting at 101° to 104°.

Workup

  1. additionthe temperature rising to 30° at the end of the addition
  2. temperatureThe reaction mixture was then warmed to 40° for 3 hours
  3. temperaturefinally heated
  4. temperatureat reflux (85°) for 2 hours
  5. customthe aqueous layer separated
  6. washthe upper ether layer being washed three times with water
  7. dry with materialAfter drying over sodium sulfate
  8. customyielding 176.3 grams of crude product
  9. customThe crude product was crystallized form heptane

Sources & evidence

ORD record
ord-fe1c7548ce6f4dc994da03e0449b1188
Source dataset
uspto-grants-1978_03
Patent number
US04081475

Reaction notes

Loading…