Dimethylformamide → HCID 86735588, compound

Participants

Reaction Steps

To a cold (ice bath) solution of H-Ala-Gly-OMe.CH3CO2H (45 mmoles, described in Example 1) in dimethylformamide (50 ml) is added N-ethylmorpholine (pH~8) followed by a cold solution of Boc-Gly-OTcp (18 g, 45 mmoles) in dimethylformamide (50 ml). The solution is kept in an ice bath for 2 days. The solvent is evaporated and the product purified by column chromatography on silica gel using ethyl acetate-methanol-pyridine 98:1:1. The product is crystallized from ethyl acetate-petroleum ether to give the title compound; m.p. 98° - 100° C; nmr (DMSO-d6); 1.25 δ (3H), 1.4 δ (9H), 3.68 δ (3H).

Provenance & Evidence