Dimethylformamide → HCID 86735590, compound

Participants

Reaction Steps

To a cold (ice bath), stirred solution of H-Gly-Ala-Gly-OMe.CH3CO2H (6.4 g, 20.03 mmoles, described in Example 3) in dimethylformamide (30 ml) is added N-ethylmorpholine (2.8 ml) followed by a solution of Boc-Gly-OTcp (8.5 g; 24 mmoles) in dimethylformamide (20 ml). The solution is kept in an ice bath for 2 days. The solvent is evaporated, the residue dissolved in methanol and the product precipitated with diethyl ether. Crystallization from ethyl acetate gives the title compound; mp 103° - 105° and 141° C (dimorphic); nmr 1.25 δ (3H), 1.38 δ (9H), 3.65 δ (3H).

Provenance & Evidence