HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-(3-Chlorophenoxy)nicotinoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-(3-Chlorophenoxy)nicotinic acid | HCID 12202641 | — |
| Catalyst | Triethylamine hydrochloride | HCID 11130 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 2-(3-Chlorophenoxy)nicotinoyl chloride | HCID 22612112 | 98.3% |
Reaction Steps
In the same manner as in Example 1(a), 22.1 grams 2(3-chlorophenoxy)nicotinic acid, 13.0 grams (0.1 mole) thionyl chloride, 0.5 grams triethylamine hydrochloride and 200 milliliters chloroform were combined to yield 23.2 grams (98.3% of theoretical) of 2(3-chlorophenoxy) nicotinoyl chloride, m.p. 72°-74° C. The structure was confirmed by mass spectrometry.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04270946 |
| Source dataset | uspto-grants-1981_06 |
| ORD ID | ord-f9b4be72bfa94ab384dd0b7bf118a7ef |
| Source note | uspto-grants-1981_06 |