HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluidine → 2-(3-chlorophenoxy)N-(4-methylphenyl)nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluidine | HCID 7813 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-(3-Chlorophenoxy)nicotinoyl chloride | HCID 22612112 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-(3-chlorophenoxy)N-(4-methylphenyl)nicotinamide | HCID 12894427 | — |
Reaction Steps
In the same manner as in Example 1(b), 1.1 grams (0.01 mole) 2(3-chlorophenoxy) nicotinoyl chloride, 1.0 grams (0.01 mole) 4-methylaniline, 1.0 grams (0.01 mole) triethylamine and 125 milliliters toluene were combined to yield 2.4 grams (70.9% of theoretical yield) of the desired product, m.p. 140°-143° C. The structure was confirmed by mass spectrometry.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04270946 |
| Source dataset | uspto-grants-1981_06 |
| ORD ID | ord-4435580ea0974395af6c5108ee2c69a4 |
| Source note | uspto-grants-1981_06 |