1-Chloro-4-(trifluoromethyl)benzene → HCID 12905997, compound

HRID 1679806Notes

Reaction equation

HRID 1679806 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][CH:3]=1.[OH:12][C:13]1[CH:24]=[CH:23][C:16]([O:17][CH:18]([CH3:22])[C:19]([NH2:21])=[O:20])=[CH:15][CH:14]=1.[OH-].[K+]>CS(C)=O>[F:9][C:8]([F:11])([F:10])[C:5]1[CH:6]=[CH:7][C:2]([O:12][C:13]2[CH:14]=[CH:15][C:16]([O:17][CH:18]([CH3:22])[C:19]([NH2:21])=[O:20])=[CH:23][CH:24]=2)=[CH:3][CH:4]=1

Participants

5

Reactant 3

HCID 73941-Chloro-4-(trifluoromethyl)benzeneHCID 14797Potassium HydroxideHCID 12852994HCID 12852994, compound

Product 1

HCID 12905997HCID 12905997, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

18 g of p-chloro-α,α,α-trifluorotoluene and 18 g of α-(p-hydroxyphenoxy)propionamide were dissolved in 50 ml of dimethyl sulfoxide, and 5.6 g of potassium hydroxide was added. The reaction was performed at 130° to 150° C. for about 5 hours. After the reaction, the reaction product was purified in a customary manner to afford the final product having a melting point of 157° to 158° C. The yield was 50%.

Workup

  1. customAfter the reaction
  2. customthe reaction product was purified in a customary manner

Sources & evidence

ORD record
ord-0d5f648905e246df9df7bc2a7e13c307
Source dataset
uspto-grants-1981_06
Patent number
US04270948

Reaction notes

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