HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxyaniline → HCID 23458158, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxyaniline | HCID 7000 | — |
| Reactant | Ethyl Acetoacetate | HCID 8868 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | p-Toluenesulfonic acid | HCID 6101 | — |
| Catalyst | Platinum | HCID 23939 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 23458158 | HCID 23458158 | 62.8% |
Reaction Steps
A mixture of 123.0 g (1 mole) of o-anisidine, 260.0 g (2 moles) of ethylacetoacetate, 400 ml of isopropyl alcohol, 10.0 g of 1% Pt/C, 2.5 g of p-toluenesulfonic acid is treated in an autoclave at 165° C., with 1000 psi of hydrogen until the uptake of hydrogen ceases. The catalyst is removed by filtration. The solution is distilled under vacuum to yield 149.0 g of ethyl 3(2'-methoxyphenylamino)butyrate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04271071 |
| Source dataset | uspto-grants-1981_06 |
| ORD ID | ord-098e62d128ac49ee867b4ab84c08c89e |
| Source note | uspto-grants-1981_06 |