反应详情

12.92 Grams (40 mmols) of Z-Thr-(tBu)-OMe in 200 ml of glacial acetic acid and 3 g of palladium carbon (10% Pd) are hydrogenated at room temperature. The absorption of hydrogen ceases after one hour. The catalyst is filtered off and the filtrate evaporated at 35° C. in a water-jet vacuum. The residue is dried in a high vacuum at 35° C. and yields 7.3 g of an oil which is unitary according to its thin-layer chromatogram and can be further used as it is.

1. customare hydrogenated at room temperature
2. customThe absorption of hydrogen ceases after one hour
3. filtrationThe catalyst is filtered off
4. customthe filtrate evaporated at 35° C. in a water-jet vacuum
5. customThe residue is dried in a high vacuum at 35° C.