HCID 131712252, compound → HCID 131712251, compound

HRID 1679836Notes

Reaction equation

HRID 1679836 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:15]([NH:17][C@H:18]([C:23]([NH:25][C@H:26]([C:32]([NH:34][C@H:35]([C:40]([OH:42])=[O:41])[CH2:36][C:37](=[O:39])[NH2:38])=[O:33])[CH2:27][CH2:28][C:29](=[O:31])[NH2:30])=[O:24])[C@H:19]([CH2:21][CH3:22])[CH3:20])=[O:16])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[CH:6][CH:5]=1>C(O)(=O)C.[C].[Pd]>[NH2:1][C@H:2]([C:15]([NH:17][C@H:18]([C:23]([NH:25][C@H:26]([C:32]([NH:34][C@H:35]([C:40]([OH:42])=[O:41])[CH2:36][C:37](=[O:39])[NH2:38])=[O:33])[CH2:27][CH2:28][C:29](=[O:31])[NH2:30])=[O:24])[C@H:19]([CH2:21][CH3:22])[CH3:20])=[O:16])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]([CH3:12])([CH3:13])[CH3:14])=[CH:6][CH:5]=1

Participants

4

Reactant 1

HCID 131712252HCID 131712252, compound

Product 1

HCID 131712251HCID 131712251, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 176Acetic AcidSolvent

Procedure

A solution of 1.2 g of the tetrapeptide derivative obtained sub (3) in 50 ml of 90% acetic acid is hydrogenated in the presence of 0.5 g of palladium carbon (10% Pd). On completion of the hydrogenation the catalyst is suctioned off, the filtrate evaporated to dryness under vacuum and the residue dried at 40° C. under a high vacuum.

Workup

  1. customthe filtrate evaporated to dryness under vacuum
  2. customthe residue dried at 40° C. under a high vacuum

Sources & evidence

ORD record
ord-791bf4db3a344ccab2b5dc86c347cfa1
Source dataset
uspto-grants-1981_06
Patent number
US04271068

Reaction notes

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