Thionyl Chloride → HCID 12923029, compound

HRID 1679884Notes

Reaction equation

HRID 1679884 reaction equation
[CH3:1][CH:2]([C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[CH2:11][CH:10]([CH2:15][CH3:16])[CH2:9]2)[C:3](O)=[O:4].S(Cl)([Cl:19])=O>C1C=CC=CC=1>[CH3:1][CH:2]([C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[CH2:11][CH:10]([CH2:15][CH3:16])[CH2:9]2)[C:3]([Cl:19])=[O:4]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 12627897HCID 12627897, compound

Product 1

HCID 12923029HCID 12923029, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A solution of 57 g of 2-methyl-(2-ethylindan-5-yl)acetic acid and 40 ml of thionyl chloride in 200 ml of benzene is heated under reflux for 2 hours. The solvent and the excess thionyl chloride are then evaporated off in vacuo. The resulting oil is then distilled in vacuo. 56 g of 2-methyl-(2-ethylindan-5-yl)-acetic acid chloride are thus recovered in the form of a liquid:

Workup

  1. temperatureunder reflux for 2 hours
  2. customThe solvent and the excess thionyl chloride are then evaporated off in vacuo
  3. distillationThe resulting oil is then distilled in vacuo
  4. custom56 g of 2-methyl-(2-ethylindan-5-yl)-acetic acid chloride are thus recovered in the form of a liquid

Sources & evidence

ORD record
ord-d0d5156d62db44b49dd21949abc6f49a
Source dataset
uspto-grants-1981_06
Patent number
US04271161

Reaction notes

Loading…