(2,6-Dichlorophenyl)acetonitrile → HCID 12904733, compound

HRID 1679899Notes

Reaction equation

HRID 1679899 reaction equation
[NH2:1][C:2]1[C:7]([CH:8]=O)=[C:6]([CH3:10])[N:5]=[C:4]([CH3:11])[N:3]=1.[Cl:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[C:14]=1[CH2:20][C:21]#[N:22]>>[Cl:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[C:14]=1[C:20]1[C:21]([NH2:22])=[N:1][C:2]2[N:3]=[C:4]([CH3:11])[N:5]=[C:6]([CH3:10])[C:7]=2[CH:8]=1

Participants

3

Reactant 2

HCID 76678(2,6-Dichlorophenyl)acetonitrileHCID 234585724-Amino-2,6-dimethylpyrimidine-5-carbaldehyde

Product 1

HCID 12904733HCID 12904733, compound

Procedure

4-Amino-2,6-dimethylpyrimidine-5-carboxaldehyde is then condensed with 2,6-dichlorophenylacetonitrile. The product is isolated and purified in the manner described in Example 6, yielding 6-(2,6-dichlorophenyl)-2,4-dimethylpyrido[2,3-d]pyrimidin-7-amine, mp 239°-240° C., after recrystallization from ethyl acetate.

Workup

  1. customThe product is isolated
  2. custompurified in the manner

Sources & evidence

ORD record
ord-8aada82a4e8346e6afd8255a1e59b831
Source dataset
uspto-grants-1981_06
Patent number
US04271164

Reaction notes

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