反应详情

6.0 g (29.8 millimoles) of 2-(p-aminophenyl)-3,4-diaza-bicyclo[4.1.0]hept-2-en-5-one (see Example 8a) and 30 ml of formic acid are refluxed for 1 hour. The solution is then poured into 500 ml of water and the precipitate which separates out is filtered off, washed with water and recrystallized from a methanol/water mixture. 4.6 g (67% of theory) of 2-(p-formylaminophenyl)-3,4-diaza-bicyclo[4.1.0]hept-2-en-5-one are isolated as almost colorless crystals, of melting point 239°-240° C.

1. filtrationthe precipitate which separates out is filtered off
2. washwashed with water
3. customrecrystallized from a methanol/water mixture