Water → HCID 23458562, compound

Participants

Reaction Steps

6.0 g (29.8 millimoles) of 2-(p-aminophenyl)-3,4-diaza-bicyclo[4.1.0]hept-2-en-5-one (see Example 9b), 4.2 g (45.4 millimoles) of propionyl chloride and 100 ml of anhydrous toluene are kept at 80° C. for 6 hours. The product is then filtered off at 10° C., washed first with toluene and then with water, and dried under reduced pressure at 50° C. 6.5 g (83% of theory) of 2-(p-propionylaminophenyl)-3,4-diaza-bicyclo[4.1.0]hept-2-en-5-one, hydrated with one mole of water per four moles of compound, are obtained as almost colorless crystals, of melting point 252°-253° C. after recrystallization from a dimethylformamide/water mixture.

Provenance & Evidence