HCID 54423379, compound → HCID 54118816, compound

Participants

Reaction Steps

5.0 g (24.4 millimoles) of cis-2-(p-aminobenzoyl)-cyclopropanecarboxylic acid (see Example 9a) and 50 ml of propionic anhydride are kept at 80° C. for 30 minutes. The solution is then poured into ice water. The oil which hereupon separates out is left to stand overnight at room temperature in the aqueous phase, during which time it solidifies. It is then filtered off, washed with water and recrystallized from ethyl acetate/petroleum ether. 1.9 g (30% of theory) of cis-2-(p-propionylaminobenzoyl)-cyclopropanecarboxylic acid are isolated as colorless crystals of melting point 182°-183° C.

Provenance & Evidence