2,2-Difluoroacetyl chloride → HCID 70571914, compound

Participants

Reaction Steps

3.0 g (14.9 millimoles) of 2-(p-aminophenyl)-3,4-diaza-bicyclo[4.1.0]hept-2-en-5-one, 2.0 g (17.5 millimoles) of difluoroacetyl chloride and 100 ml of absolute tetrahydrofuran are kept first for 3 hours at 0°-5° C. and then for 20 hours at room temperature. The product is filtered off at 10° C., washed with water and recrystallized from methanol. 2.7 g (63% of theory) of 2-(p-difluoroacetylaminophenyl)-3,4-diaza-bicyclo[4.1.0]hept-2-en-5-one hemihydrate are obtained as colorless crystals, of melting point 223°-224° C.

Provenance & Evidence