Sodium Hydroxide → HCID 23458683, compound

Participants

Reaction Steps

A 5.5 N aqueous solution of sodium hydroxide (36 cc) is added in the course of 5 minutes, at 22°-23° C., to a suspension of 3-chloro-2-oxopropyl acetate (29.9 g) in distilled water (500 cc). The hydrolysis reaction is allowed to proceed for 15 minutes at 22° C. and triethylammonium pyrid-2-yldithiocarbamate (53.6 g) is then added in the course of 5 minutes at a maximum of 23° C. The reaction is allowed to proceed for 2 hours at 20°-23° C. The crystals which have appeared are filtered off, washed with distilled water (50 cc) and then with ethyl ether (50 cc) and dried under reduced pressure (0.1 mm Hg) at 45° C. 4-Hydroxy-4-hydroxymethyl-3-(pyrid-2-yl)-thiazolidine-2-thione (12.0 g), which melts at 134°-135° C., is thus obtained.

Provenance & Evidence