Acetic Acid → HCID 23458400, compound

Participants

Reaction Conditions

Reaction Steps

To a well stirred mixture of 2-[α-(2-methoxy-phenoxy)-2-chloro-benzyl]-morpholine (2 g) in glacial acetic acid (5.2 ml), acetone (12 ml) and water (8 ml), NaBH4 (6.024 g) was added over 1 hour maintaining the temperature near 0° C. Then more acetone (12 ml) and NaBH4 (3 g) were added; the temperature was allowed to rise to room temperature and after 30 hours the reaction mixture was poured into a solution of NaHCO3 in water, then extracted with diethyl ether. The ethereal extracts were washed with water, dried over Na2SO4 and evaporated to dryness to give 4-isopropyl-2-[α-(2-methoxy-phenoxy)-2-chloro-benzyl]-morpholine (1.85 g; yield 82.3%) .HCl m.p. 200°-240° C.

Provenance & Evidence