HCID 15572629, compound → HCID 13398586, compound

Participants

Reaction Steps

To a solution of 7 g of 2-[α-(2-nitro-phenoxy)-benzyl]-4-methyl-morpholin-5-one in 200 ml of DMF, 5% Palladium-charcoal (0.7 g) was added and the mixture was hydrogenated at 3.5 atmospheres for 0.5 hours. The catalyst was filtered off, the solution was poured into water and then extracted with ethyl acetate. After anhydrification and evaporation to dryness of the solvent, crystallization from ethyl ether gave 2-[α-(2-amino-phenoxy)-benzyl]-4-methyl-morpholin-5-one, m.p. 167°-170° C. (5.3 g; 75.2%).

Provenance & Evidence