Methylamine → HCID 23458432, compound

Participants

Reaction Steps

4 g of ethyl 2-ethoxycarbonylmethyloxy-3-phenyl-3-(2-methoxyphenoxy)propionate dissolved in 30 ml of ethanol was heated in an autoclave at 150° C. for 20 hours with 20 ml of a 10% ethanolic solution of methylamine. Cooling was allowed to take place and the solvent was removed under reduced pressure. The residue was crystallized from ethanol to obtain 2.26 g of 2-[α-(2-methoxyphenoxy)-benzyl]-4-methyl-morpholin-3,5-dione. Yield 64%.

Provenance & Evidence