HCID 70577004, compound → HCID 70574870, compound

Participants

Reaction Steps

Under a hydrogen pressure of 3.2 kg/cm2 and in the presence of 4.4 g of palladium on carbon (10% Pd), a solution of 4.4 g (0.091 mole) of benzyl 1'-methyl-6-(2-phenylacetamido)-spiro[penam-2,4'-piperidine]-3-carboxylate prepared in I.1.a) in 800 ml of ethanol are hydrogenolyzed in a Parr's apparatus for 1 hour. After filtering, the precipitate is digested in 1.5 liter of a 9:1 v/v methanol-water mixture for 1 hour. Evaporation of the filtrate to dryness gives 1.6 g of 1'-methyl-6-(2-phenylacetamido)-spiro[penam-2,4'-piperidine]-3-carboxylic acid. Yield: 44.8%; M.P. 189°-190° C. (decomposition).

Provenance & Evidence